Understanding Why the Immune System Fails to Destroy Lingering Senescent Cells May Lead to New Senolytic Therapies

The accumulation of lingering senescent cells in all tissues is one of the causes of aging. Even in very late life, senescent cells are thought to account for only a few percent at most of all cells in any given tissue, but they cause great disruption to tissue structure and function: chronic inflammation, impaired regeneration, fibrosis, and other unpleasant outcomes. This is accomplished via an as yet incompletely cataloged mix of secreted molecules known as the senescence-associated secretory phenotype, or SASP. Acting via secretions allows a small number of cells to have large effects. When present for a limited period of time, senescent cells are helpful, a necessary part of wound healing, embryonic development, and suppression of cancer. Cells become senescent in response to the circumstance

From https://www.fightaging.org/archives/2019/06/understanding-why-the-immune-system-fails-to-destroy-lingering-senescent-cells-may-lead-to-new-senolytic-therapies/

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from https://aubreyflores.blogspot.com/2019/06/understanding-why-immune-system-fails.html

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From https://tommysmith1.blogspot.com/2019/06/understanding-why-immune-system-fails.html